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Lung cancer

Researchers at The Ottawa Hospital are investigating promising new approaches to prevent, diagnose and treat lung cancer. This page includes selected news stories about our lung cancer research, links to researchers working in this area and related resources.

Research News


Reinvigorating immunotherapy: clinical trial provides new hope for lung cancer patients Reinvigorating immunotherapy: clinical trial provides new hope for lung cancer patients
February 23, 2024 - The Ottawa Hospital played a key role in an international clinical trial that is providing new hope for people with advanced non-small cell lung cancer (NSCLC).
Immunotherapy improves survival with mesothelioma lung cancer Immunotherapy improves survival with mesothelioma lung cancer
January 4, 2024 - An international clinical trial published in The Lancet shows that immunotherapy improves survival in people with an aggressive type of lung cancer called pleural mesothelioma.
Capturing immunotherapy response in a blood drop Capturing immunotherapy response in a blood drop
October 26, 2023 - A clinical trial published in Nature Medicine suggests that using a “liquid biopsy” to measure tiny bits of tumour DNA in blood could determine if immunotherapy drugs are working in patients with advanced non-small cell lung cancer.
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Researchers


Name Scientific appointment Diseases, conditions and populations of interest Research and clinical approaches
Addison, Christina
PhD
Senior Scientist
(CR)
Bone and joint degeneration, Cancer, Lung cancer, Lung disease, Pancreatic cancer, Prostate cancer, Breast cancer Basic research, Clinical research, Cohort studies, Disease models, Drug development, Genetics, Imaging, Model organisms, Translational research, Molecular and cellular biology
Ardolino, Michele
PhD
Senior Scientist
(CR)
Blood cancer, Brain cancer, Breast cancer, Cancer, Colorectal cancer, Head and neck cancer, Liver cancer, Lung cancer, Ovarian cancer, Pancreatic cancer, Prostate cancer, Skin cancer, Soft tissue sarcoma Basic research, Cancer immunotherapy, Cell therapy, Clinical research, Disease models, Immunization, Immunotherapy, Model organisms, Molecular and cellular biology, Transgenic/knockout models, Translational research
Gilbert, Sebastien
MD FRCSC
Clinician Investigator
(ACR)
Cancer, Gastric cancer, Gastrointestinal disease, Gastrointestinal stromal tumours (GIST), Lung cancer, Lung disease Artificial intelligence and data science, Clinical research, Epidemiology, Health technology, Quality Improvement
Gray, Douglas
PhD
Senior Scientist Emeritus
(CR)
Aging, Cancer, Lung cancer, Parkinson's Basic research, Disease models, Genomics, Imaging, Transgenic/knockout models, Genetics, Model organisms, Molecular and cellular biology
Islam, Shahidul
MD, PhD, FRCPC, FCAP
Clinician Investigator
(CR)
Cancer, Endometrial cancer, Lung cancer, Ovarian cancer, Thyroid cancer
Patino, Paula
MD
Clinician Investigator
(ICD)
Lung cancer
Ramsay, Timothy
PhD
Senior Scientist
(MIR)
Addiction, Alzheimer's, Amyotrophic lateral sclerosis, Anxiety, Ataxia, Attention deficit hyperactivity disorder (ADHD), Autism, Bipolar, Brain and neuromuscular disease, Chronic obstructive pulmonary disease, Colorectal cancer, Concussion, Cystic fibrosis, Dementia, Depression, First Nations, Inuit and Métis Health, HIV, Immigrant and refugee health, Influenza, Kidney disease, Lung cancer, Macular degeneration, Men's health, Multiple sclerosis, Muscular dystrophy, Myasthenia gravis, Obesity, Ovarian cancer, Parkinson's, Pulmonary hypertension, Septic shock, Spinal cord injury Artificial intelligence and data science, Behaviour, Biomaterials, Biostatistics, Cell therapy, Clinical decision rules, Clinical research, Clinical trials, Cohort studies, Critical care, Drug development, Emergency medicine, Epidemiology, Health professional behaviour change, Health promotion, Health research methods, Health services research, Health technology, Immunization, Immunotherapy, Palliative care, Patient decision aids, Pharmacology, Pharmacy, Prevention, Psychology, Psychometrics, Public health, Qualitative methods, Quality Improvement, Regenerative medicine, Rehabilitation, Risk assessment, Shared decision making, Surgery, Surveys, Systematic reviews, Transfusions, Translational research, Transplantation, Viral therapy
Stanford, William
PhD
Senior Scientist
(RM)
Aging, Blood cancer, Cancer, COVID-19, Lung cancer, Lymphangioleiomyomatosis (LAM), Vascular, heart and metabolic disease Artificial intelligence and data science, Molecular and cellular biology, Regenerative medicine, Stem cells, Systems biology




Clinical Trials

The following list of clinical trials is pulled from ClinicalTrials.gov using the search terms "Lung cancer” and “Ottawa Hospital.” More advanced search options are available. If you find a clinical trial that interests you, you can bring the information to the next appointment with your care team and ask if you are eligible for the study. If so, they may be able to refer you to the study team. Visit ohri.ca/patients to learn more about participating in research and clinical trials.

Note that ClinicalTrials.gov is hosted by the U.S. National Library of Medicine and is only available in English. Please note that we cannot guarantee a response from the person listed in the ‘Contact’ column.

NCTTitleConditionStatusContact
NCT04895709A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors (NCT04895709)Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Urothelial Carcinoma, Pancreatic Adenocarcinoma, Melanoma, Ovarian Neoplasms, Triple Negative Breast NeoplasmsRECRUITING 
NCT05571839A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors (NCT05571839)Cutaneous Melanoma, Non-small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Neoplasms, MesotheliomaRECRUITING 
NCT06012435A Study of Sigvotatug Vedotin Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer (Be6A Lung-01). (NCT06012435)Carcinoma, Non-Small-Cell LungRECRUITING 
NCT04260802A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers (NCT04260802)Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer, Gastric Cancer, Cervical Cancer, Ovarian Cancer, Hepatocellular Carcinoma, Squamous Cell Carcinoma of Head and Neck, Urothelial Carcinoma, Urothelial Neoplasm, Non Small Cell Lung Cancer, Renal Cell Carcinoma, Locally Advanced Solid Tumor, Locally Advanced Malignant Neoplasm, Squamous Cell Carcinoma, Sarcoma, Merkel Cell Carcinoma, Bladder CancerRECRUITING 
NCT04449874A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation (NCT04449874)Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid TumorsRECRUITING 
NCT05538130A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors (NCT05538130)Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal CancerRECRUITING 
NCT05355701A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations. (NCT05355701)Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, GliomaRECRUITING 
NCT04609566Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors (NCT04609566)Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and NeckRECRUITING 
NCT02468024JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer (NCT02468024)Non-Small Cell Lung CancerRECRUITINGsgilbert@toh.ca; afazekas@toh.ca
NCT05714891Neoadjuvant Platform Trial in Non-Small Cell Lung Cancer (NCT05714891)NSCLCRECRUITING 
NCT02906943Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (NCT02906943)Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma, Gynecological Cancer, Genitourinary Cancer, Pancreatobiliary Cancer, Gastrointestinal Cancer, Head and Neck Cancer, Rare Cancer, Unknown Primary CancerRECRUITING 
NCT04335292Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer with Osimertinib Third-line Rechallenge (NCT04335292)Non-Small Cell Lung CancerRECRUITING 
NCT04613596Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7 (NCT04613596)Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung CancerRECRUITING 
NCT04093167Study of CTDNA Response Adaptive Immuno-Chemotherapy in NSCLC (NCT04093167)Non-Small Cell Lung CancerRECRUITING 
NCT04871412The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III (NCT04871412)Lung Cancer, Gastric Cancer, Esophageal CancerRECRUITING 
NCT04894591To Assess the Effectiveness and Safety of Zepzelca in Adult Patients With Extensive Stage Small Cell Lung Cancer (SCLC) (NCT04894591)Extensive-stage Small-cell Lung CancerRECRUITING 


Publications

The following research publications are pulled from PubMed using the search terms "Lung cancer" and "Ottawa Hospital", with publication date of 2020 or later. More advanced search options are available. Note that PubMed is hosted by the U.S. National Library of Medicine and is only available in English.

Update on Practical Management of Early-Stage Non-Small Cell Lung Cancer (NSCLC): A Report from the Ontario Forum.
2024-11-26

The Supportive Care Needs of Individuals Living With Advanced or Metastatic Lung Cancer Receiving Targeted or Immunotherapies.
2024-10-30

Implementation of Liquid Biopsy in Non-Small-Cell Lung Cancer: An Ontario Perspective.
2024-10-25

Pulmonary Nocardiosis in a Non-Small Cell Lung Cancer Patient Being Treated for Pembrolizumab-Associated Pneumonitis.
2024-10-25

A Phase II Study of Neoadjuvant Opnurasib KRAS G12C Inhibitor in Patients With Surgically Resectable Non-Small Cell Lung Cancer (CCTG IND.242A): A Substudy of the IND.242 Platform Master Protocol.
2024-10-12

Appendicitis while on alectinib for non-small cell lung cancer: a tale of two case reports.
2024-10-11

Pathways to cancer care after a suspected cancer diagnosis in the emergency department: a survey of emergency physicians across Ontario.
2024-10-07

Ponsegromab for the Treatment of Cancer Cachexia.
2024-09-17

Treatment patterns and outcomes in KRAS(G12C)-positive advanced NSCLC patients previously treated with immune checkpoint inhibitors: A Canada-wide real-world, multi-center, retrospective cohort study.
2024-07-30

Long-Term Prospective Outcomes of Intensity Modulated Radiotherapy for Locally Advanced Lung Cancer: A Secondary Analysis of a Randomized Clinical Trial.
2024-06-27

View more on PubMed