Ottawa Hospital Research Institute

Research News

	Researchers at The Ottawa Hospital awarded 18 CIHR grants worth more than $11 million February 5, 2022 - These projects will advance science and improve health in areas such as tuberculosis, blood disease, prostate cancer, heart disease, muscle repair, sleep apnea, brain cancer, medical imaging, virtual care, prehab, intellectual disability, sarcoma, CA
	A glimpse inside the mind of neurosurgery expert, Dr. Fahad Alkherayf August 18, 2021 - Dr. Fahad Alkherayf is the Director of the Clinical Research Program in the Neurosurgery Division of The Ottawa Hospital. As a neurosurgeon, he specializes in minimally invasive surgeries, which use much smaller incisions than traditional surgeries
	Researchers discover new kind of brain tumour July 8, 2019 - Dr. John Woulfe and his colleagues have identified a new kind of brain tumour. It was removed during a young woman’s treatment, and did not match any existing tumour classifications.
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	New scientist profile: Dr. Fahad AlKherayf aims to improve minimally invasive brain surgery June 26, 2019 - Neurosurgeon Dr. Fahad AlKherayf specializes in removing tumours from the base of the skull that are normally difficult for the surgeon to access by operating through the nose. His research aims to improve this minimally invasive technique.
	Using stem cells to treat brain cancer: pilot study highlights potential new approach August 16, 2018 - Stem cells are usually associated with repairing damaged tissue and treating degenerative diseases, but they also have a unique property that may be harnessed to fight cancer. When injected into the body, stem cells naturally migrate to tumours, and
	Electromagnetic field therapy improves survival in brain cancer patients January 19, 2018 - A JAMA study co-authored by Dr. Garth Nicholas shows that a wearable device that transmits low-intensity electrical fields into the brain can prolong survival in people with a highly aggressive form of brain cancer. The randomized trial included ne
	Researchers find potential new treatment target for deadly brain cancer April 25, 2016 - A team of researchers has found a key player in brain tumour formation that may lead to new therapies for a deadly and incurable cancer. The study published in Nature Neuroscience is the first to show that a protein called OSMR (Oncostatin M

Researchers

Name	Scientific appointment	Diseases, conditions and populations of interest	Research and clinical approaches
Ardolino, Michele PhD	Senior Scientist (CR)	Blood cancer, Brain cancer, Breast cancer, Cancer, Colorectal cancer, Head and neck cancer, Liver cancer, Lung cancer, Ovarian cancer, Pancreatic cancer, Prostate cancer, Skin cancer, Soft tissue sarcoma	Basic research, Cancer immunotherapy, Cell therapy, Clinical research, Disease models, Immunization, Immunotherapy, Model organisms, Molecular and cellular biology, Transgenic/knockout models, Translational research
Aviv, Richard MBChB, FRCR (UK), FRCPC, dABR	Clinician Investigator (NS)	Brain and neuromuscular disease, Brain cancer, Head and neck cancer, Multiple sclerosis, Stroke, Subarachnoid hemorrhage, Traumatic brain injury, Vascular cognitive impairment, Vascular, heart and metabolic disease	Artificial intelligence and data science, Basic research, Big data, Bioinformatics, Biomarkers, Clinical research, Cluster randomized trials, Disease models, Health economics, Health technology, Imaging, Patient safety, Quality Improvement, Translational research
Chakraborty, Santanu MBBS, MRCP, DMRD, FRCR, FRCP(C)	Senior Clinician Investigator (NS)	Amyotrophic lateral sclerosis, Brain cancer, Concussion, Dementia, Head and neck cancer, Multiple sclerosis, Parkinson's, Spinal cord injury, Stroke, Traumatic brain injury	Bioinformatics, Clinical research, Health economics, Health professional behaviour change, Imaging, Immunization, Patient safety, Quality Improvement, Risk assessment
Lorimer, Ian PhD	Senior Scientist (CR)	Brain and neuromuscular disease, Brain cancer, Cancer	Basic research, Cancer biotherapeutics, Cell therapy, Disease models, Molecular and cellular biology, Translational research
Nair, Vimoj MBBS MD MSc FRCPC	Clinician Investigator (CR)	Blood cancer, Brain cancer, Colorectal cancer, Gastric cancer, Liver cancer, Pancreatic cancer	Artificial intelligence and data science, Biostatistics, Cancer biotherapeutics, Clinical research, Clinical trials, Health technology, Imaging, Pragmatic trials, Quality Improvement, Translational research
Puac Polanco, Paulo MD	Clinician Investigator (NS)	Brain cancer, Head and neck cancer, Stroke	Imaging
Santos, Marlise MD (FRCPC), MSc, MPH	Clinician Investigator (NS)	Alzheimer's, Anxiety, Ataxia, Autoimmune disease, Autoimmune diseases of the nervous system, Blood cancer, Brain and neuromuscular disease, Brain cancer, Cancer, Concussion, Dementia, Depression, Global health, Head and neck cancer, Health equity, Health in disadvantaged peoples, Infectious disease, Intellectual disabilities, Multiple sclerosis, Parkinson's, Population health, Sickle cell anemia, Spinal cord injury, Stroke, Subarachnoid hemorrhage, Thrombosis / thromboembolism, Traumatic brain injury, Traumatic injuries, Vascular cognitive impairment, Vascular, heart and metabolic disease	Artificial intelligence and data science, Basic research, Behaviour, Biostatistics, Cancer biotherapeutics, Clinical decision rules, Clinical research, Clinical trials, Cohort studies, Critical care, Epidemiology, Health economics, Health research methods, Health services research, Health technology, Imaging, Patient safety, Pragmatic trials, Prevention, Public health, Qualitative methods, Quality Improvement, Shared decision making, Surgery, Surveys, Systematic reviews
Woulfe, John PhD, MD	Associate Scientist (NS)	Brain and neuromuscular disease, Brain cancer, Cancer, Parkinson's	Basic research, Clinical research, Translational research

Related Resources

Ottawa Hospital Research Institute Cancer Therapeutics Program

The Ottawa Hospital Cancer Program

Clinical Trials

The following list of clinical trials is pulled from ClinicalTrials.gov using the search terms "(brain cancer OR glioblastoma OR glioma OR medulloblastoma)” and “Ottawa Hospital.” More advanced search options are available. If you find a clinical trial that interests you, you can bring the information to the next appointment with your care team and ask if you are eligible for the study. If so, they may be able to refer you to the study team. Visit ohri.ca/patients to learn more about participating in research and clinical trials.

Note that ClinicalTrials.gov is hosted by the U.S. National Library of Medicine and is only available in English. Please note that we cannot guarantee a response from the person listed in the ‘Contact’ column.

Publications

The following research publications are pulled from PubMed using the search terms "brain cancer OR glioblastoma OR glioma OR medulloblastoma" and "Ottawa Hospital", with publication date of 2020 or later. More advanced search options are available. Note that PubMed is hosted by the U.S. National Library of Medicine and is only available in English.

Master regulators of neurogenesis: the dynamic roles of Ephrin receptors across diverse cellular niches.
2024-11-07

Atlas of gray matter volume differences across psychiatric conditions: A systematic review with a novel meta-analysis that considers co-occurring disorders.
2024-11-04

Brain malformations and seizures by impaired chaperonin function of TRiC.
2024-11-03

Targeting glioblastoma with a brain-penetrant drug that impairs brain tumor stem cells via NLE1-Notch1 complex.
2024-10-19

Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network analyses.
2024-09-29

Combination treatment with histone deacetylase and carbonic anhydrase 9 inhibitors shows therapeutic potential in experimental diffuse intrinsic pontine glioma.
2024-09-24

Global and risk-group stratified well-being and mental health during the COVID-19 pandemic in adults: Results from the international COH-FIT Study.
2024-09-22

Gadolinium Reduction in Brain Tumor Imaging: A Paradigm Shift in Diagnostic Strategies.
2024-08-27

HNRNPA1 de novo Variant Associated with Early Childhood Onset, Rapidly Progressive Generalized Myopathy.
2024-08-09

Perception of pneumocystis jirovecii pneumonia (PJP) prophylaxis in glioma patients receiving concurrent temozolomide and radiation- a patient and physician survey.
2024-08-06

View more on PubMed