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Research sheds light on how testosterone regulates female reproduction
avril 7, 2017
Androgens such as testosterone are best known for promoting the development of the male reproductive system, as well as muscles and body hair. Androgens are also present in women and play a role in female reproduction and infertility, but the exact mechanism is unclear.
Dr.
Benjamin Tsang
and his team have found that a protein called RING (Really Interesting New Gene) Finger 6 may play an important role in this. They found that the active form of testosterone, dihydrotestosterone, increase the amount of RING finger 6 in rat ovaries, and this helps start a molecular cascade that results in release of an egg. They also show that this system is very sensitive to the amount of testosterone and when it appears during ovary growth and egg development.
This research could improve our understanding of polycystic ovary syndrome, a leading cause of infertility in women which is associated with high androgen levels.
See
Endocrinology
for details.
Authors:
Lim JJ, Han CY, Lee DR Tsang BK.
Funders:
Canadian Institutes of Health Research, National Research Foundation of Korea
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The Ottawa Hospital is one of Canada’s largest learning and research hospitals with over 1,100 beds, approximately 12,000 staff and an annual budget of over $1.2 billion. Our focus on research and learning helps us develop new and innovative ways to treat patients and improve care. As a multi-campus hospital, affiliated with the University of Ottawa, we deliver specialized care to the Eastern Ontario region, but our techniques and research discoveries are adopted around the world. We engage the community at all levels to support our vision for better patient care. See www.ohri.ca for more information about research at The Ottawa Hospital.
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Jennifer Ganton
Director, Communications and Public Relations
Ottawa Hospital Research Institute
Office: 613-798-5555 x 73325
Cell: 613-614-5253
jganton@ohri.ca
Tags:
Infertility
,
Women's health