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Des chercheurs de L’Hôpital d’Ottawa bénéficient de 10 subventions des IRSC évaluées à plus de 7 M$


le 21 juillet 2025

Des chercheurs de L’Hôpital d’Ottawa ont reçu plus de 7 M$ des Instituts de recherche en santé du Canada (IRSC) pour diriger 10 projets de recherche de pointe. Ces projets feront progresser la science et amélioreront la santé dans divers domaines, comme les neurosciences, la maladie du foie, la sclérodermie systémique, le cancer de l’ovaire, la santé des mères et des nourrissons, le cancer du sein, les soins à un proche, la dépression bipolaire, la confiance à l’égard des soins de santé, les atteintes rénales de la sclérose tubéreuse et la gestion des antibiotiques.

« Grâce à ces subventions, nous pourrons effectuer des percées révolutionnaires en sciences biomédicales et élaborer de meilleures options de traitement pour les patients, ici même, à L’Hôpital d’Ottawa et dans le monde entier », explique la Dre Rebecca Auer,, vice-présidente exécutive, Recherche et Innovation à L’Hôpital d’Ottawa, PDG et directrice scientifique de l’Institut de recherche de l’Hôpital d’Ottawa ainsi que professeure à l’Université d’Ottawa. « L’obtention d’un tel financement témoigne de la créativité, du dévouement et de l’esprit de collaboration de nos chercheurs et de leurs équipes. »

L’Hôpital d’Ottawa se classe actuellement au 4e rang des hôpitaux financés par les IRSC au Canada.

Subventions de recherche des IRSC administrées à l’Institut de recherche de l’Hôpital d’Ottawa (IRHO)

Monoacylglycerol lipase (Mgll)-regulated 2-AG/eCBR signaling in feeding circuits controls adult neurogenesis-$1,309,680

  • Principal Investigator(s): Wang, Jing

Identifying CD8 T Cell Immunometabolic Scars in Chronic HCV and Metabolic Liver Disease and Their Impact on HCC Responses-$1,296,676

  • Principal Investigator(s): Crawley, Angela Marie
  • Co-Investigator(s): Ardolino, M; Cheung, A; Cooper, CL

Canadian-Made CD19 CAR-T Therapy for Refractory Systemic Sclerosis, from the Canadian Led Immunotherapies Collaborative (CLIC-03 Trial)-$1,216,351

  • Principal Investigator(s): Kekre, Natasha; Hay, KA, Holt, R, Hudson, M, Maltez, N
  • Co-Investigator(s): Assouline, SE; Atkins, HL; Cherniawsky, HM; Fergusson, DA; Hu, A; Nelson, BH; Quizi, JL

Targeting cancer cell plasticity to improve outcomes in high-grade serous ovarian cancer- $1,025,100

  • Principal Investigator(s): Cook, David Parker
  • Co-Investigator(s): Mackay, HJ; Nelson, BH; Rahimi, K

Assessing maternal and infant health outcomes following immunization for respiratory syncytial virus (RSV) disease-$646,426

  • Principal Investigator(s): El-Chaar, Darine; Buchan, S; Fitzpatrick, T; Kwong, JC; Morris, SK; Walker, MC
  • Co-Investigator(s): Alton, GD; Brophy, JC; Ducharme, R; Dunn, SI; Fakhraei, R; Guttmann, A; Harvey, A; Hawken, S; Hui, C; Jorgensen, SC; Murphy, MS; Pham-Huy, A; Rennicks White, R; Reszel, J; Scremin Souza, S; Silverberg, S; Sprague, A; St.hill, A; Wilson, K; Wilson, S; Wong, KT

A pragmatic, multicenter randomized study evaluating the benefits and risks of adjuvant endocrine therapy in patients aged 70 years or older with low-risk breast cancer (REaCT-70 Study)-$600,000

  • Principal Investigator(s):  Savard, Marie-France; Clemons, MJ; Pond, GR
  • Co-Investigator(s): D Ahmed, S; Bashir, A; Hsu, T; Hutton, BE; Khan, OF; Mithoowani, H; Thavorn, K; Wilkinson, AN

Leveraging a New National Data Linkage to Examine Caregiving for Older Adults and Its Impacts on Caregivers' Downstream Outcomes-$546,976

  • Principal Investigator(s): Manuel, Douglas G
  • Co-Investigator(s): Backman, C; Cole, KM; Engel, FD; Fisher, SL; Fung, S; Hsu, AT; Li, W; Manis, D; Myran, D; Okamoto, R; Stall, NM; Taler, V; Webber, C

Canadian Extension of the Candesartan Adjunctive Bipolar Depression Trial (CADET)- $405,451

  • Principal Investigator(s): Fiedorowicz, Jess G; Solmi, M
  • Co-Investigator(s): Dargél, AA; Mcgirr, A; Mikhail, E; Raedler, TJ; Saraf, G

Building and sustaining trust in healthcare: Co-developing a compendium of equitable strategies for building, rebuilding and maintaining trust-$100,000

  • Principal Investigator(s):  Presseau, Justin; Auer, RC; Meyer, S; Smith, MM
  • Co-Investigator(s): Albers, B; Brehaut, JC; Desveaux, L; Dogba, MA; Dombrowski, S; Etherington, C; Fontaine, G; Heer, C; Hsu, AT; Ivers, NM; Lavis, JN; Macpherson, PA; Manuel, DG; Nicholls, SG; Olson, JL; Vesnaver, E; Wilson, K; Wilson, MG

Cellular and molecular pathogenesis of renal tuberous sclerosis complex-$100,000

  • Principal Investigator(s): Stanford, William Lloyd

Subventions de recherche et d’équipe des IRSC administrées dans un autre établissement – projets comptant des chercheurs principaux de l’IRHO 

CanFos: Improving the Health of Canadian Children in Foster Homes - $638,776

  • Principal Investigator(s): Evans, Andrea; Manuel, Douglas G; Quinn, Ashley L
  • Co-Investigator(s): Ali, Samina; Alqurashi, Waleed; Barrowman, Nicholas J; Brown, Hilary; Halverson, Julie; Kassam, Altaf; Racine, Nicole M; Saunders, Natasha R; Trocme, Nico; Urquia, Marcelo L; Vandermorris, Ashley
  • Note: This grant is administered at CHEO Research Institute

PD-TIPS.AI: Co-Designing AI-Driven Bilingual Self-Care Technology Delivering Tailored Care Tips and Resources for Parkinson's Disease - $585,224

  • Principal Investigator(s): Grosjean, Sylvie; Mestre, Tiago
  • Co-Investigator(s): Chomienne, Marie-Hélène; Grimes, David A; Inkpen, Diana M; Jutai, Jeffrey W; Lessard, Lysanne; Rahgozar, Arya
  • Note: this grant is administered at the University of Ottawa

A feasibility study of a context specific antibiotic stewardship intervention among physicians in Nigeria’s private outpatient facilities - $481,950

  • Principal Investigator(s): Sulis, Giorgia; OgaOmenka, C
  • Co-Investigator(s): Albers, B; Dodd, WH; Eriobu, NC; Gandra, S; Gbenro, VK; Kwaghe, VG; Peters, SE; Presseau, J; Taljaard, M; Yahaya, R
  • Note: this grant is administered at the University of Ottawa

A cluster randomized controlled trial of BornFyne Prenatal Management System digital platform to support reproductive maternal care delivery in Cameroon - $451,352

  • Nguilefem, Miriam N; Boubacar Moumouni, Aissata; Little, Julian; Taljaard, Monica
  • Buh, Amos; Goldstein, Cory E; Mabeu, Marie Christelle; Pongou, Roland; Udenigwe, Ogochukwu C; Welch, Vivian A
  • Note: this grant is administered at Bruyère Health Research Institute

Effectiveness of alcohol warning labels on consumer knowledge and perceptions of alcohol health risks and on alcohol use: a randomized field experiment to inform alcohol labelling policy

  • Principal Investigator(s): Hobin, Erin P; Corace, Kimberly M
  • Co-Investigator(s): Britz-Mckibbin, Philip; Cukier, Samantha; Cunningham, John A; Hammond, David G; Li, Ye; Meyer, Samantha; Naimi, Timothy; Sherk, Adam N; Smith, Brendan; Stockwell, Timothy R; Thompson, Kara D; Vanderlee, Lana M
  • Note: This grant is administered at Public Health Ontario (Toronto)

L’Hôpital d’Ottawa est un centre universitaire de pointe dans le domaine de la recherche et de la santé et un hôpital d’enseignement fièrement affilié à l’Université d’Ottawa. Ses travaux de recherche sont appuyés par la Fondation de l’Hôpital d’Ottawa. Renseignez-vous sur le financement de la recherche.