Des chercheurs de L’Hôpital d’Ottawa sont à la barre de 19 nouveaux projets qui ont reçu un financement de plus de 12 millions de dollars des Instituts de recherche en santé du Canada (IRSC).

Ces projets feront avancer les connaissances scientifiques et amélioreront la santé dans des domaines comme le cancer, la neuroscience, la médecine régénératrice, l’autisme, le syndrome Kabuki, les maladies rénales, l’engagement du patient, les transfusions sanguines, la sepsie, la chirurgie, l’anesthésie, le don de plasma, les maladies musculaires, les lésions pulmonaires graves, les lésions pulmonaires chez le nouveau-né et la syncope.

« Ces projets de recherche nous permettent d’offrir d’excellents soins aux patients tout en réalisant des percées scientifiques qui améliorent la santé à l’échelle mondiale », affirme le Dr Duncan Stewart, vice-président exécutif de la Recherche à L’Hôpital d’Ottawa et professeur à l’Université d’Ottawa.

L’Institut de recherche de l’Hôpital d’Ottawa a obtenu un taux de succès de 34 % dans ce concours, la moyenne nationale se situant à 22 %. Au cours des trois dernières années, L’Hôpital d’Ottawa s’est classé 4^e en moyenne parmi les hôpitaux financés par les IRSC.

Les projets sont présentés ci-dessous dans la langue dans laquelle ils ont été fournis par le chercheur.

A possible treatment to ameliorate autism spectrum disorders - $1,174,276

• Principal Investigator(s): Chen, Hsiao-Huei

Role for defective enhancer commissioning in the hypotonia phenotype of Kabuki Syndrome patients - $937,126

• Principal Investigator(s): Dilworth, Jeffrey

Intraoperative pharmacologic opioid minimization strategies and patient-centred outcomes after surgery: a scoping review - $100,000

• Principal Investigator(s): Fergusson, Dean A; Lalu, Manoj M
• Co-Investigator(s): Bérubé, Mélanie; Gilron, Ian; Graham, Megan; Hutton, Brian E; Martel, Guillaume; McIsaac, Daniel I; McVicar, Jason; Moloo, Husein; Nicholls, Stuart G; Poulin, Patricia A; Turgeon, Alexis F; Verret, Michael

Artificial Intelligence for the Prevention of Unplanned Dialysis - $195,000

• Principal Investigator(s): Hundemer Gregory; Akbari, Ayub; Klein, Ran; McCudden, Christopher; Thavorn, Kednapa
• Co-Investigator(s): Goupil, Remi; Green, James; Klamrowski, Martin; MacKinnon, Martin; Molnar, Amber; Nadeau-Fredette, Annie-Claire; Oliver, Matthew J; Ramsay, Timothy O; Ravani, Pietro; Sood, Manish M; Tangri, Navdeep; White, Christine A

Knowledge Syntheses to Identify Best Treatments for Cancer Related Neurocognitive Dysfunction in Cancer Survivors - $99,450

• Principal Investigator(s): Hutton, Brian E; Arnaout, Angel; Clemons, Mark J
• Co-Investigator(s): Fallah, Parvaneh; Hamel, Candyce; Kanji, Salmaan; Larocque, Gail; McGee, Sharon; Ng, Terry L; Rabheru, Kiran; Rice, Danielle B

Designing oncolytic rhabdoviruses for horizontal delivery of artificial microRNAs - $852,976

• Principal Investigator(s): Ilkow Carolina S
• Co-Investigator(s): Ardolino, Michele

Patient engagement in basic science: co-development and pilot evaluation of a novel framework - $504,900

• Principal Investigator(s): Lalu, Manoj M, Fergusson, Dean A; Richards, Dawn
• Co-Investigator(s): Crawley, Angela M; Fiest, Kirsten M; Hendrick, Kathryn; Macala, Kimberly; Mendelson, Asher A; Messner, Pat; Nicholls, Stuart G; Presseau, Justin; Séguin, Cheryle A; Sullivan, Patrick; Thebaud, Bernard

A Delphi survey to generate consensus among international experts on elements of an intraoperative transfusion protocol - $72,676

• Principal Investigator(s): Martel, Guillaume; Fergusson, Dean A
• Co-Investigator(s): Hallet, Julie; Jerath, Angela; Lalu, Manoj M; Lenet, Tori; McIsaac, Daniel I; Nicholls, Stuart G; Presseau, Justin; Tinmouth, Alan T; Turgeon, Alexis F; Verret, Michael; Wherrett, Christopher

DRAGON 2 - An international multicenter randomized controlled trial to compare combined Portal and Hepatic Vein Embolization (PVE/HVE) with PVE alone in liver surgery - $642,868

• Principal Investigator(s): Martel, Guillaume, Fergusson, Dean A
• Co-Investigator(s): Ball, Chad G; Bennett, Sean; Bertens, Kimberly Bertens A; Chaudhury, Prosanto K; Collin, Yves; Gallinger, Steven; Jayaraman, Shiva; Karanicolas, Paul J; Korenblik, Remon; Menard, Alexandre; Metrakos, Peter P; Moser, Michael; Ruo, Leyo; Ryan, Stephen; Segedi, Maja; Skaro, Anton I; Smits, Jens; Thavorn, Kednapa; Van Dam, Ronald M; van der Leij, Christiaan; Vandenbroucke-Menu, Franck; Walsh, Mark J

A Cluster Randomized Cross-over Trial of an Antibiotic Decision Support Intervention in Sepsis (IDEAS II) - $300,000

• Principal Investigator(s): MacFadden, Derek R; Daneman, Nick
• Co-Investigator(s): Elligsen, Marion; Graham, Christopher; Lam, Philip W; Nott, Caroline; Suh, Kathryn N; Taljaard, Monica

The Anesthesia for Lower limb revascularization to Optimize Functional OuTcomes (ALOFT) Trial: a pilot multicenter randomized trial - $202,725

• Principal Investigator(s): McIsaac, Daniel I; Jerath, Angela; Kidd, Gurlavine D; Roberts, Derek J; Saha, Tarit; Taljaard, Monica; Wijeysundera, Duminda N
• Co-Investigator(s): Boet, Sylvain; Bragg, Susan; Bryson, Gregory L; Carrier, François M; de Mestral, Charles; Dubois, Daniel G; Fergusson, Dean A; Flexman, Alana M; Grudzinski, Alexa L; Kayssi, Ahmed; Lalu, Manoj M; Lee, Susan M; MacDonald, David B; McCartney, Colin J; Mccluskey, Stuart A; McKeen, Dolores M; Nagpal, Sudhir; Parotto, Matteo; Spence, Jessica; Thavorn, Kednapa; Uppal, Vishal; Van Walraven, Carl

Expanding source plasma donation in Canada: Enhancing the capability, opportunity, and motivation of under-represented Canadians to donate plasma - $761,176

• Principal Investigator(s): Presseau, Justin; Dogba, Maman A; MacPherson, Paul A
• Co-Investigator(s): Devine, Dana V; Haw, Jennie; Holloway, Kelly J; Meyer, Samantha; O’Brien, Sheila F; Sekhon, Mandy; Shorr, Risa; Vesnaver, Elisabeth; Welch, Vivian A

Muscle Stem Cell Function in Duchenne Muscular Dystrophy - $1,071,000

• Principal Investigator(s): Rudnicki, Michael A

Dissecting the roles of the Polycomb protein MTF2 in leukemogenesis - $956,250

• Principal Investigator(s): Stanford, William L
• Co-Investigator(s): Berman, Jason N; Hendzel, Michael J; Ito, Caryn; Sabloff, Mitchell

Microvascular Endothelial Loss and Regeneration in Acute Lung Injury - $1,178,100

• Principal Investigator(s): Stewart, Duncan J
• Co-Investigator(s): Oudit, Gavin Y

Multi-Centre Cluster-Randomized Implementation of Canadian Syncope Pathway for Emergency Department Syncope Management - $1,250,776

• Principal Investigator(s): Thiruganasambandamoorthy, Venkatesh
• Co-Investigator(s): Archambault, Patrick; Chan, Kenneth K; Cheung, Ka Wai; Cheung, Warren J; Clark, Greg; Cournoyer, Alexis; Desveaux, Laura; ELLIS, Paul D; Fabian, Jaroslav C; Franc, Jeffrey M; Gazarin, Mohamed; Grant, Lars; Harris, Devin R; Hegdekar, Mona; Krahn, Andrew D; McRae, Andrew D; Mercier, Eric; Morris, Judy M; Nowacki, ANNA K; Ohle, Robert; Ouyang, Yongdong; Raj, Satish R; Rouleau, Geneviève; Savage, David; Seifer, Colette; Sevcik, Bill (William); Sivilotti, Marco L; Staples, John A; Taljaard, Monica; Tanuseputro, Peter; Toarta, Cristian; Yan, Justin

Role of Membrane-Associated Guanylate Kinases (MAGUKs) in Dopamine Receptor Signaling - $921,826

• Principal Investigator(s): Tiberi, Mario

Endothelial progenitor cell-based therapies for neonatal pulmonary hypertension - $975,376

• Principal Investigator(s): Thébaud, Bernard
• Co-Investigator(s): Burger, Dylan

Ethical issues in cluster randomized trials: using stakeholder and patient engagement to generate guidance for the ethical design and conduct of trials evaluating clinical, health policy, health systems, and public health interventions - $531,674

• Principal Investigator(s): Weijer, Charles E; Taljaard, Monica
• Co-Investigator(s): Althabe, Fernando; Binik, Ariella; Brehaut, Jamie C; Eldridge, Sandra; Ferrand, Rashida A; Gillies, Katie; Giraudeau, Bruno; Goldstein, Cory E; Grimshaw, Jeremy M; Hemkens, Lars; Hemming, Karla; Johri, Mira; Kim, Scott Y; Largent, Emily; Leese, Jennifer; London, Alex J; Magwood, Olivia; Marlin, Susan; Mbuagbaw, Lawrence C; Mitchell, Susan; Nicholls, Stuart G; Petkovic, Jennifer; Treweek, Shaun P; Tugwell, Peter S; van der Graaf, Rieke; Welch, Vivian A
• Note: this grant is administered at the University of Western Ontario

Ces projets bénéficient de l’appui de ressources fondamentales en recherche à L’Hôpital d’Ottawa, notamment le Centre de méthodologie d’Ottawa.

L’Hôpital d’Ottawa est un centre universitaire de pointe dans le domaine de la recherche et de la santé et un hôpital d’enseignement fièrement affilié à l’Université d’Ottawa.