Researchers at The Ottawa Hospital are playing a lead role in 19 new projects awarded more than $12 million from the Canadian Institutes of Health Research (CIHR).
These projects will advance science and improve health in areas such as cancer, neuroscience, regenerative medicine, autism, Kabuki Syndrome, kidney disease, patient engagement, blood transfusions, sepsis, surgery, anesthesia, plasma donation, muscle disease, acute lung injury, neonatal lung injury and syncope.
“These research projects will help us provide the best care possible for our patients and community, while advancing science and improving health on a global scale,” said Dr. Duncan Stewart, Executive Vice-President of Research at The Ottawa Hospital and professor at the University of Ottawa.
The Ottawa Hospital Research Institute had a success rate of 34 percent in this competition compared to the national average of 22 percent. Over the last three years, The Ottawa Hospital has held an average rank of #4 among hospitals for CIHR funding.
The new grants include:
A possible treatment to ameliorate autism spectrum disorders - $1,174,276
Role for defective enhancer commissioning in the hypotonia phenotype of Kabuki Syndrome patients - $937,126
Intraoperative pharmacologic opioid minimization strategies and patient-centred outcomes after surgery: a scoping review - $100,000
- Principal Investigator(s): Fergusson, Dean A; Lalu, Manoj M
- Co-Investigator(s): Bérubé, Mélanie; Gilron, Ian; Graham, Megan; Hutton, Brian E; Martel, Guillaume; McIsaac, Daniel I; McVicar, Jason; Moloo, Husein; Nicholls, Stuart G; Poulin, Patricia A; Turgeon, Alexis F; Verret, Michael
Artificial Intelligence for the Prevention of Unplanned Dialysis - $195,000
- Principal Investigator(s): Hundemer Gregory; Akbari, Ayub; Klein, Ran; McCudden, Christopher; Thavorn, Kednapa
- Co-Investigator(s): Goupil, Remi; Green, James; Klamrowski, Martin; MacKinnon, Martin; Molnar, Amber; Nadeau-Fredette, Annie-Claire; Oliver, Matthew J; Ramsay, Timothy O; Ravani, Pietro; Sood, Manish M; Tangri, Navdeep; White, Christine A
Knowledge Syntheses to Identify Best Treatments for Cancer Related Neurocognitive Dysfunction in Cancer Survivors - $99,450
- Principal Investigator(s): Hutton, Brian E; Arnaout, Angel; Clemons, Mark J
- Co-Investigator(s): Fallah, Parvaneh; Hamel, Candyce; Kanji, Salmaan; Larocque, Gail; McGee, Sharon; Ng, Terry L; Rabheru, Kiran; Rice, Danielle B
Designing oncolytic rhabdoviruses for horizontal delivery of artificial microRNAs - $852,976
- Principal Investigator(s): Ilkow Carolina S
- Co-Investigator(s): Ardolino, Michele
Patient engagement in basic science: co-development and pilot evaluation of a novel framework - $504,900
- Principal Investigator(s): Lalu, Manoj M, Fergusson, Dean A; Richards, Dawn
- Co-Investigator(s): Crawley, Angela M; Fiest, Kirsten M; Hendrick, Kathryn; Macala, Kimberly; Mendelson, Asher A; Messner, Pat; Nicholls, Stuart G; Presseau, Justin; Séguin, Cheryle A; Sullivan, Patrick; Thebaud, Bernard
A Delphi survey to generate consensus among international experts on elements of an intraoperative transfusion protocol - $72,676
- Principal Investigator(s): Martel, Guillaume; Fergusson, Dean A
- Co-Investigator(s): Hallet, Julie; Jerath, Angela; Lalu, Manoj M; Lenet, Tori; McIsaac, Daniel I; Nicholls, Stuart G; Presseau, Justin; Tinmouth, Alan T; Turgeon, Alexis F; Verret, Michael; Wherrett, Christopher
DRAGON 2 - An international multicenter randomized controlled trial to compare combined Portal and Hepatic Vein Embolization (PVE/HVE) with PVE alone in liver surgery - $642,868
- Principal Investigator(s): Martel, Guillaume, Fergusson, Dean A
- Co-Investigator(s): Ball, Chad G; Bennett, Sean; Bertens, Kimberly Bertens A; Chaudhury, Prosanto K; Collin, Yves; Gallinger, Steven; Jayaraman, Shiva; Karanicolas, Paul J; Korenblik, Remon; Menard, Alexandre; Metrakos, Peter P; Moser, Michael; Ruo, Leyo; Ryan, Stephen; Segedi, Maja; Skaro, Anton I; Smits, Jens; Thavorn, Kednapa; Van Dam, Ronald M; van der Leij, Christiaan; Vandenbroucke-Menu, Franck; Walsh, Mark J
A Cluster Randomized Cross-over Trial of an Antibiotic Decision Support Intervention in Sepsis (IDEAS II) - $300,000
- Principal Investigator(s): MacFadden, Derek R; Daneman, Nick
- Co-Investigator(s): Elligsen, Marion; Graham, Christopher; Lam, Philip W; Nott, Caroline; Suh, Kathryn N; Taljaard, Monica
The Anesthesia for Lower limb revascularization to Optimize Functional OuTcomes (ALOFT) Trial: a pilot multicenter randomized trial - $202,725
- Principal Investigator(s): McIsaac, Daniel I; Jerath, Angela; Kidd, Gurlavine D; Roberts, Derek J; Saha, Tarit; Taljaard, Monica; Wijeysundera, Duminda N
- Co-Investigator(s): Boet, Sylvain; Bragg, Susan; Bryson, Gregory L; Carrier, François M; de Mestral, Charles; Dubois, Daniel G; Fergusson, Dean A; Flexman, Alana M; Grudzinski, Alexa L; Kayssi, Ahmed; Lalu, Manoj M; Lee, Susan M; MacDonald, David B; McCartney, Colin J; Mccluskey, Stuart A; McKeen, Dolores M; Nagpal, Sudhir; Parotto, Matteo; Spence, Jessica; Thavorn, Kednapa; Uppal, Vishal; Van Walraven, Carl
Expanding source plasma donation in Canada: Enhancing the capability, opportunity, and motivation of under-represented Canadians to donate plasma - $761,176
- Principal Investigator(s): Presseau, Justin; Dogba, Maman A; MacPherson, Paul A
- Co-Investigator(s): Devine, Dana V; Haw, Jennie; Holloway, Kelly J; Meyer, Samantha; O'Brien, Sheila F; Sekhon, Mandy; Shorr, Risa; Vesnaver, Elisabeth; Welch, Vivian A
Muscle Stem Cell Function in Duchenne Muscular Dystrophy - $1,071,000
Dissecting the roles of the Polycomb protein MTF2 in leukemogenesis - $956,250
- Principal Investigator(s): Stanford, William L
- Co-Investigator(s): Berman, Jason N; Hendzel, Michael J; Ito, Caryn; Sabloff, Mitchell
Microvascular Endothelial Loss and Regeneration in Acute Lung Injury - $1,178,100
Multi-Centre Cluster-Randomized Implementation of Canadian Syncope Pathway for Emergency Department Syncope Management - $1,250,776
- Principal Investigator(s): Thiruganasambandamoorthy, Venkatesh
- Co-Investigator(s): Archambault, Patrick; Chan, Kenneth K; Cheung, Ka Wai; Cheung, Warren J; Clark, Greg; Cournoyer, Alexis; Desveaux, Laura; ELLIS, Paul D; Fabian, Jaroslav C; Franc, Jeffrey M; Gazarin, Mohamed; Grant, Lars; Harris, Devin R; Hegdekar, Mona; Krahn, Andrew D; McRae, Andrew D; Mercier, Eric; Morris, Judy M; Nowacki, ANNA K; Ohle, Robert; Ouyang, Yongdong; Raj, Satish R; Rouleau, Geneviève; Savage, David; Seifer, Colette; Sevcik, Bill (William); Sivilotti, Marco L; Staples, John A; Taljaard, Monica; Tanuseputro, Peter; Toarta, Cristian; Yan, Justin
Role of Membrane-Associated Guanylate Kinases (MAGUKs) in Dopamine Receptor Signaling - $921,826
Endothelial progenitor cell-based therapies for neonatal pulmonary hypertension - $975,376
Ethical issues in cluster randomized trials: using stakeholder and patient engagement to generate guidance for the ethical design and conduct of trials evaluating clinical, health policy, health systems, and public health interventions - $531,674
- Principal Investigator(s): Weijer, Charles E; Taljaard, Monica
- Co-Investigator(s): Althabe, Fernando; Binik, Ariella; Brehaut, Jamie C; Eldridge, Sandra; Ferrand, Rashida A; Gillies, Katie; Giraudeau, Bruno; Goldstein, Cory E; Grimshaw, Jeremy M; Hemkens, Lars; Hemming, Karla; Johri, Mira; Kim, Scott Y; Largent, Emily; Leese, Jennifer; London, Alex J; Magwood, Olivia; Marlin, Susan; Mbuagbaw, Lawrence C; Mitchell, Susan; Nicholls, Stuart G; Petkovic, Jennifer; Treweek, Shaun P; Tugwell, Peter S; van der Graaf, Rieke; Welch, Vivian A
- Note: this grant is administered at the University of Western Ontario
These projects are supported by core resources for research at The Ottawa Hospital, such as the Ottawa Methods Centre.
The Ottawa Hospital is a leading academic health, research and learning hospital proudly affiliated with the University of Ottawa and supported by The Ottawa Hospital Foundation.
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