Des chercheurs de L’Hôpital d’Ottawa sont à la barre de 15 nouveaux projets qui ont reçu un financement de plus de 8.4 millions de dollars des Instituts de recherche en santé du Canada (IRSC).

Les projets visent des avancées en science et en santé dans des domaines comme la grossesse, la santé mentale, les maladies neuromusculaires, le cancer, les thromboses veineuses, les maladies infectieuses, l’application des connaissances, les examens diagnostiques, les maladies pulmonaires et l’AVC.

« Les projets de recherche de ce type nous permettent d’offrir d’excellents soins aux patients tout en réalisant des percées scientifiques qui améliorent la santé à l’échelle mondiale », affirme le Dr Duncan Stewart, vice-président exécutif de la Recherche à L’Hôpital d’Ottawa et professeur à l’Université d’Ottawa. « Je suis fier que L’Hôpital d’Ottawa figure continuellement parmi les hôpitaux qui obtiennent les subventions les plus généreuses des IRSC, décrochant la quatrième place en 2022-2023. »

Les nouvelles subventions comprennent les suivantes :

The maternal endothelium in gestational diabetes mellitus - $860,625

• Principal Investigator(s): Burger, Dylan; Shah, Baiju R; Dolinsky, Vernon W

Infant and child health outcomes following SARS-CoV-2 infection in pregnancy - $100,000

• Principal Investigator(s): El-Chaar, Darine; Brophy, Jason C; Hawken, Steven
• Co-Investigator(s): Walker, Mark C; Fell, Deshayne B; Dunn, Sandra I; Corsi, Daniel J; Pham-Huy, Anne; Cameron, D.William; Cook, Jocelynn L; Muldoon, Katherine A; Murphy, Malia S; Van Lieshout, Ryan J Kharrat, Ashraf; Carsley, Sarah; Ducharme, Robin

Development of a suicide prevention strategy for Public Safety Personnel - $650,251

• Principal Investigator(s): Hatcher, Simon
• Co-Investigator(s): Carleton, R. Nicholas, Ricciardelli, Rose, Kennedy, Sidney H, Dmetrichuk, Jennifer, Devlin, Julie H, Mishara, Brian L, Cramm, Heidi, Shields, Norman M, Heber, Alexandra, DuBois, Denise MacDermid, Joy C, Genest, Christine

Extra-neuronal contribution to spinal muscular atrophy disease pathogenesis - $818,550

• Principal Investigator(s): Kothary, Rashmi K

PREVENT GU: Prevention of thromboembolism with rivaroxaban in GU cancer patients receiving chemotherapy: A Randomized Placebo-Controlled, Double-Blind Clinical Trial - $424,575

• Principal Investigator(s): Lavallée, Luke T; Breau, Rodney H; Bossé, Dominick; Carrier, Marc
• Co-Investigator(s): Cagiannos, Ilias; Mallick, Ranjeeta; Fergusson, Dean A; Wang, Tzu-Fei; Reaume, Martin N; McAlpine, Kristen; Winquist, Eric; Hotte, Sebastien; Lazo-Langner, Alejandro; Ikesaka, Rick T Lalani, Aly-Khan; Morash, Chris G; Sridhar, Srikala S; Ong, Michael; Canil, Christina M; Huynh, Melissa

A Randomized Controlled Non-Inferiority Trial to Assess the Utility of Non-Targeted Biopsies for Colorectal Neoplasia Detection in Adult Inflammatory Bowel Disease - $650,249

• Principal Investigator(s): Murthy, Sanjay K; Fergusson, Dean A
• Co-Investigator(s): Jairath, Vipul; Bernstein, Charles N; Riddell, Robert H; Nguyen, Geoffrey C

Epigenetic Regulation of the Adenovirus Genome- $696,150

• Principal Investigator(s): Parks, Robin J

Evaluating and Improving a National Learning Network- $619,650

• Principal Investigator(s): Seely, Andrew J; Brehaut, Jamie C; Taljaard, Monica
• Co-Investigator(s): Ferri, Lorenzo; Finley, Christian J; Kidane, Biniam; Moffatt-Bruce, Susan D; Presseau, Justin; Ramsay, Timothy O; Thavorn, Kednapa; Villeneuve, Patrick J

AMSTAR-DTA: A Measurement Tool to Assess Systematic Reviews of Diagnostic Test Accuracy Studies -$100,000

• Principal Investigator(s): Shea, Beverley J
• Co-Investigator(s): Henry, David A; Moher, David; Welch, Vivian A; Hamel, Candyce; Reeves, Barnaby C; McInnes, Matthew; Tugwell, Peter S; Wells, George A

Reducing Gastrointestinal Bleeding with Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism (RADIANT) Pilot Randomized Trial - $543,149

• Principal Investigator(s): Siegal, Deborah M; Delluc, Aurelien
• Co-Investigator(s): Rodger, Marc A; Skeith, Leslie; Abdulrehman, Jameel; Gross, Peter L Wang, Tzu-Fei; Carrier, Marc; Xu, Yan; Castellucci, Lana; Barkun, Alan N; Forbes, Nauzer; Ramsay, Timothy O

Imbalance Between Vascular Injury and Repair in PAH- $868, 275

• Principal Investigator(s): Stewart, Duncan J

Therapeutic potential of stem cells in lung injury -$100,000

• Principal Investigator(s): Thébaud, Bernard

Increasing anti-tumoral responses to ovarian cancer using engineered viruses- $906,525

• Principal Investigator(s): Vanderhyden, Barbara C
• Co-Investigator(s): Auer, Rebecca Ann C; Rodriguez, Galaxia M; Cook, David P

ACT WHEN Randomized Controlled Trial - $1,575,899

• Principal Investigator(s): Menon, Bijoy K; Almekhlafi, Mohammed A; Dowlatshahi, Dariush
• Co-Investigator(s): Alhabli, Ibrahim; Ben-Israel, David; Buck, Brian H; Catanese, Luciana; Demchuk, Andrew M; Ganesh, Aravind; Hill, Michael D; Joundi, Raed; Katsanos, Aristeidis; Kim, Beom Joon; Poppe, Alexandre Y; Sajobi, Tolulope T; Shankar, Jai J; Singh, Nishita; Swartz, Richard; Thavorn, Kednapa; Tkach, Aleks
• Note: this grant is administered at the University of Calgary

These projects are supported by core resources for research at The Ottawa Hospital, such as the Ottawa Methods Centre.

The Ottawa Hospital is a leading academic health, research and learning hospital proudly affiliated with the University of Ottawa and supported by The Ottawa Hospital Foundation. 

Media Contact 

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